Chemical evolution of the Galactic Center

In recent years, the Galactic Center (GC) region (200 pc in radius) has been studied in detail with spectroscopic stellar data as well as an estimate of the ongoing star formation rate. The aims of this paper are to study the chemical evolution of the GC region by means of a detailed chemical evolution model and to compare the results with high resolution spectroscopic data in order to impose constraints on the GC formation history.The chemical evolution model assumes that the GC region formed by fast infall of gas and then follows the evolution of alpha-elements and Fe. We test different initial mass functions (IMFs), efficiencies of star formation and gas infall timescales. To reproduce the currently observed star formation rate, we assume a late episode of star formation triggered by gas infall/accretion. We find that, in order to reproduce the [alpha/Fe] ratios as well as the metallicity distribution function observed in GC stars, the GC region should have experienced a main early strong burst of star formation, with a star formation efficiency as high as 25 Gyr^{-1}, occurring on a timescale in the range 0.1-0.7 Gyr, in agreement with previous models of the entire bulge. Although the small amount of data prevents us from drawing firm conclusions, we suggest that the best IMF should contain more massive stars than expected in the solar vicinity, and the last episode of star formation, which lasted several hundred million years, should have been triggered by a modest episode of gas infall/accretion, with a star formation efficiency similar to that of the previous main star formation episode. This last episode of star formation produces negligible effects on the abundance patterns and can be due to accretion of gas induced by the bar. Our results exclude an important infall event as a trigger for the last starburst.Comment: 10 pages, 8 figures, accepted for publication in MNRA

Chemical evolution of the bulge of M31: predictions about abundance ratios

We aim at reproducing the chemical evolution of the bulge of M31 by means of a detailed chemical evolution model, including radial gas flows coming from the disk. We study the impact of the initial mass function, the star formation rate and the time scale for bulge formation on the metallicity distribution function of stars. We compute several models of chemical evolution using the metallicity distribution of dwarf stars as an observational constraint for the bulge of M31. Then, by means of the model which best reproduces the metallicity distribution function, we predict the [X/Fe] vs. [Fe/H] relations for several chemical elements (O, Mg, Si, Ca, C, N). Our best model for the bulge of M31 is obtained by means of a robust statistical method and assumes a Salpeter initial mass function, a Schmidt-Kennicutt law for star formation with an exponent k=1.5, an efficiency of star formation of $\sim 15\pm 0.27\, Gyr^{-1}$, and an infall timescale of $\sim 0.10\pm 0.03$Gyr. Our results suggest that the bulge of M31 formed very quickly by means of an intense star formation rate and an initial mass function flatter than in the solar vicinity but similar to that inferred for the Milky Way bulge. The [$\alpha$/Fe] ratios in the stars of the bulge of M31 should be high for most of the [Fe/H] range, as is observed in the Milky Way bulge. These predictions await future data to be proven.Comment: Accepted for publication by MNRA

Metronomic Chemotherapy with Vinorelbine Produces Clinical Benefit and Low Toxicity in Frail Elderly Patients Affected by Advanced Non-Small Cell Lung Cancer

Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectable non-small cell lung cancer (NSCLC). Methods. From January 2016 to December 2016, 44 patients affected by non-small cell lung cancer referred to our oncology day hospital were progressively analyzed. The patients were treated with oral vinorelbine 30 mg x 3/wk or 40 mg x 3/wk meaning one day on and one day off. The patients were older than 60, stage IIIB or IV, ECOG PS ≥ 1, and have at least one important comorbidity (renal, hepatic, or cardiovascular disease). The schedule was based on ECOG-PS and comorbidities. The primary endpoint was progression-free survival (PFS). PFS was used to compare patients based on different scheduled dosage (30 or 40 mg x3/weekly) and age (more or less than 75 years old) as exploratory analysis. We also evaluated as secondary endpoint toxicity according to Common Toxicity Criteria Version 2.0. Results. Vinorelbine showed a good safety profile at different doses taken orally and was effective in controlling cancer progression. The median overall survival (OS) was 12 months. The disease control rate (DCR) achieved 63%. The median PFS was 9 months. A significant difference in PFS was detected comparing patients aged below with those over 75, and the HR value was 0.72 (p<0.05). Not significant was the difference between groups with different schedules. Conclusions. This study confirmed the safety profile of metronomic vinorelbine and its applicability for patients unfit for standard chemotherapies and adds the possibility of considering this type of schedule not only for very elderly patients

Sources Shared on Twitter: A Case Study on Immigration

The study, which aimed to better understand the types of information sources that users on one popular social media platform may see about a major national policy issue, finds that news organizations play a far larger role than other types of content providers, such as commentary or government sites.This is especially true in regards to one contentious issue: immigration

Informing decisions on the purchase of equipment used by health services in response to incidents involving hazardous materials

Accidents involving release of chemical, biological, radiological or nuclear substances may prompt the need to decontaminate exposed casualties prior to further medical treatment. Health service workers who carry out decontamination procedures wear protective suits to avoid direct contact with contaminants. We developed an analytical framework based on queueing theory to inform UK Department of Health's decisions on the stock of protective suits that ambulance services and hospitals with emergency departments in England should hold. Our aim was to ensure that such allocation gave an accepted degree of resilience to locally identified hazards. Here we give an overview of our work and describe how we incorporated information in the public domain about local hazards with expert opinion about the patterns of demand for decontamination associated with different types of incident. We also give an account of how we worked with decision makers to inform national guidance on this topic

FUCA1 is induced by wild-type p53 and expressed at different levels in thyroid cancers depending on p53 status

Fucose residues of cell surface glycans, which play important roles in growth, invasion and metastasis, are added by fucosyltransferases (FUTs) and removed by α-L-fucosidases (FUCAs). By the differential display method, we isolated a 3' non-coding region of α-L-fucosidase-1 (FUCA1) (a gene coding for the lysosomal fucosidase-1 enzyme) as a wild-type p53-inducible gene: 18S and 20S FUCA1 mRNA species were induced in Saos-2 cells transfected with a temperature-sensitive p53 mutant at the permissive temperature. By microarray analyses of thyroid cancer biopsy samples, FUCA1 RNA expression levels were found to be lower in anaplastic thyroid cancer samples (ATCs), while they were higher in papillary thyroid cancer samples (PTCs) and in normal thyroid tissues. Since most ATCs were reported to carry the mutated form of p53, while PTCs carry mostly the wild-type form of p53, it is likely that FUCA1 expression levels are regulated, at least in part, by the p53 status in thyroid cancers. In order to better understand the role played by FUCA genes in thyroid tumorigenesis, we examined the clonogenic potential in vitro of thyroid cell lines transfected with either FUCA1 or FUCA2 (the latter gene coding for a secreted, non-lysosomal enzyme). We found that α-L-fucosidases did not suppress grossly cell growth. Contrary to what we observed with the expression of FUCA1, the FUT8 expression levels were found high in ATCsbut lower in PTCs and normal thyroid tissues. Taken together, these results suggest the possibility that the higher fucose levels on cell surface glycans of aggressive ATCs, compared to those of less aggressive PTCs, may be at least in part responsible for the more aggressive and metastatic phenotype of ATCs compared to PTCs, as the expression levels of FUCA1 and FUT8 were inversely related in these two types of cancers. Fucose residues of cell surface glycans, which play important roles in growth, invasion and metastasis, are added by fucosyltransferases (FUTs) and removed by α-L-fucosidases (FUCAs). By the differential display method, we isolated a 3' non-coding region of α-L-fucosidase-1 (FUCA1) (a gene coding for the lysosomal fucosidase-1 enzyme) as a wild-type p53-inducible gene: 18S and 20S FUCA1 mRNA species were induced in Saos-2 cells transfected with a temperature-sensitive p53 mutant at the permissive temperature. By microarray analyses of thyroid cancer biopsy samples, FUCA1 RNA expression levels were found to be lower in anaplastic thyroid cancer samples (ATCs), while they were higher in papillary thyroid cancer samples (PTCs) and in normal thyroid tissues. Since most ATCs were reported to carry the mutated form of p53, while PTCs carry mostly the wild-type form of p53, it is likely that FUCA1 expression levels are regulated, at least in part, by the p53 status in thyroid cancers. In order to better understand the role played by FUCA genes in thyroid tumorigenesis, we examined the clonogenic potential in vitro of thyroid cell lines transfected with either FUCA1 or FUCA2 (the latter gene coding for a secreted, non-lysosomal enzyme). We found that α-L-fucosidases did not suppress grossly cell growth. Contrary to what we observed with the expression of FUCA1, the FUT8 expression levels were found high in ATCs but lower in PTCs and normal thyroid tissues. Taken together, these results suggest the possibility that the higher fucose levels on cell surface glycans of aggressive ATCs, compared to those of less aggressive PTCs, may be at least in part responsible for the more aggressive and metastatic phenotype of ATCs compared to PTCs, as the expression levels of FUCA1 and FUT8 were inversely related in these two types of cancers